DIAGNOSTICA IVD
DIAGNOSTICA IVD

Permeability & Immunity Markers: Fecal Zonulin and Secretory IgA (sIgA)

€70,00

Sample required: Fecal sample via Danastool tube  

Turnaround time: 2–3 weeks 

The Fecal Zonulin & Secretory IgA (sIgA) test offers a targeted analytical assessment of intestinal barrier integrity and mucosal immunity efficiency. By simultaneously measuring fecal levels of Zonulin and sIgA, the panel provides essential support for the analysis of enteric permeability, underlying inflammatory status, and the mucosal defense capacity. 

Informed consent

artt. 13 e 9 Reg. UE 2016/679 - GDPR

Required

Consent to the processing of health-related data for care purposes (section 3.a).

Required

Consent to receiving the service via teleconsultation, with the limits described in the notice.

Optional

Consent to possible recording of the session (not required for the service).

How does it work?

  • Shipment of the Danastool collection kit directly to your home. 
  • Activation and Self-collection: Completion of the online medical history form and performing the fecal self-collection at home with total ease. 
  • Shipment to the laboratory: Sending the sample using the included prepaid envelope. The Danastool system preserves the stability of the markers at room temperature without the need for a cold chain. 
  • Analysis and Reporting: The laboratory performs the immuno-enzymatic assays and releases the digital report within 2–3 weeks. 

Why choose?

  • Integrated dual investigation: Simultaneously analyzes the physical structure of the barrier (Zonulin) and its immune defense (sIgA).
  • Very early identification of Leaky Gut: Allows for the detection of states of intestinal hyperpermeability before they develop into systemic inflammation or more complex issues.
  • Non-invasive collection: The use of the Danastool vial makes collection convenient and stable for transport.
  • Personalized planning: Objective and reproducible data useful for doctors and nutritionists to define tailored nutritional strategies or supplementation protocols.

Who is it for?

This test is particularly recommended for: 

  • Evaluating and verifying suspected intestinal hyperpermeability (Leaky Gut Syndrome). 
  • Investigating the health status of the mucosa in the presence of chronic food intolerances, non-celiac gluten sensitivity, or recurrent abdominal bloating or pain. 
  • Assessing the activity and efficiency of immune defenses at the gastrointestinal level. 
  • Monitoring progress and immune response during therapeutic pathways for inflammatory bowel diseases (IBD) or dysbiosis syndromes. 
  • Investigating the clinical picture in the presence of systemic or dermatological disorders related to the gut-body axis. 

Disclaimer

  • Informational value and clinical support: The report has analytical and cognitive value. It does not in itself constitute a clinical or medical diagnosis, does not identify pathologies autonomously, and does not replace evaluation and prescription by a physician.
  • Specialist evaluation: The interpretation of Zonulin and sIgA levels must be contextualized by an attending physician or specialist within the patient's overall clinical picture.
  • Pharmacological interference: The intake of immunomodulatory, corticosteroid, or anti-inflammatory drugs in the preceding days may influence sIgA and Zonulin values. It is recommended to accurately report any therapies in the online medical history form.